Application Notes

TOC as a real-time on-line surrogate measurement of COD and BOD

InnovOx On-Line Total Organic Carbon (TOC) Analyzer provides a continuous analysis of TOC. The TOC values

can be correlated with BOD or COD values, and provide the opportunity to use the regulatory data requirement

for process optimization. In addition, the operator can retain, divert, or dilute discharges prior to causing damage.

Inadequate Instrument Qualification and Analytical Method Validation Prompting FDA Scrutiny

Many pharmaceutical companies are under the impression that simply performing an

IQ/OQ upon istallation and then a periodic calibration, verification and the USP <643>

system suitability test is all that is required for an online TOC analyser. However, this

may cause serious issues in the future when auditors arrive onsite. Be sure you

understand the latest PQ requirements and USP <1225>

PQ Update

USP 1225

How to choose the right Thermal Validation System to purchase

What are the REAL questions one should ask in order to maximise value and ensure the users are happy to work with the system you choose? Download the PDF to find out more.

Cleaning Validation eBook
Whether you are new to cleaning validation or a seasoned TOC user, this e-book will provide all levels with a wide-ranging understanding of the what, how, and why of TOC for cleaning validation.

What's Your Vial Style
Whether you’re testing for compliance, cleaning validation, or difficult-to-recover compounds, Sievers* TOC vials ensure top performance and minimize risks. Accurate, efficient, & confident – that should be your style!

Service & Maintenance Guides

Backflush procedure to clear blockage from sample lines in 900 and 5310C TOC analysers

Should your model 900 or 5310C TOC analyser develop a blockage in the sample flow system, the

backflush procedure will help you clear the flush with ease.

For more information or guidance, please contact us.

Backflush

Document Downloads

Resources

Application Notes

Document Downloads

Service & Maintenance Guides

Application Notes

TOC as a real-time on-line surrogate measurement of COD and BOD

InnovOx On-Line Total Organic Carbon (TOC) Analyzer provides a continuous analysis of TOC. The TOC values

can be correlated with BOD or COD values, and provide the opportunity to use the regulatory data requirement

for process optimization. In addition, the operator can retain, divert, or dilute discharges prior to causing damage.

Inadequate Instrument Qualification and Analytical Method Validation Prompting FDA Scrutiny

Many pharmaceutical companies are under the impression that simply performing an

IQ/OQ upon istallation and then a periodic calibration, verification and the USP <643>

system suitability test is all that is required for an online TOC analyser. However, this

may cause serious issues in the future when auditors arrive onsite. Be sure you

understand the latest PQ requirements and USP <1225>

How to choose the right Thermal Validation System to purchase

What are the REAL questions one should ask in order to maximise value and ensure the users are happy to work with the system you choose? Download the PDF to find out more.

Cleaning Validation eBook Whether you are new to cleaning validation or a seasoned TOC user, this e-book will provide all levels with a wide-ranging understanding of the what, how, and why of TOC for cleaning validation.

What's Your Vial Style Whether you’re testing for compliance, cleaning validation, or difficult-to-recover compounds, Sievers* TOC vials ensure top performance and minimize risks. Accurate, efficient, & confident – that should be your style!

Service & Maintenance Guides

Backflush procedure to clear blockage from sample lines in 900 and 5310C TOC analysers

Should your model 900 or 5310C TOC analyser develop a blockage in the sample flow system, the

backflush procedure will help you clear the flush with ease.

For more information or guidance, please contact us.

Document Downloads

Resources

Cleaning Validation eBook
Whether you are new to cleaning validation or a seasoned TOC user, this e-book will provide all levels with a wide-ranging understanding of the what, how, and why of TOC for cleaning validation.

What's Your Vial Style
Whether you’re testing for compliance, cleaning validation, or difficult-to-recover compounds, Sievers* TOC vials ensure top performance and minimize risks. Accurate, efficient, & confident – that should be your style!